KEGG   Rattus norvegicus (rat): 25591
Entry
25591             CDS       T01003                                 
Symbol
Parp1
Name
(RefSeq) poly [ADP-ribose] polymerase 1
  KO
K24070  poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno03410  Base excision repair
rno04064  NF-kappa B signaling pathway
rno04210  Apoptosis
rno04217  Necroptosis
rno05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:rno00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03410 Base excision repair
    25591 (Parp1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    25591 (Parp1)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    25591 (Parp1)
   04217 Necroptosis
    25591 (Parp1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    25591 (Parp1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:rno03032]
    25591 (Parp1)
   03036 Chromosome and associated proteins [BR:rno03036]
    25591 (Parp1)
   03400 DNA repair and recombination proteins [BR:rno03400]
    25591 (Parp1)
Enzymes [BR:rno01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.2  Pentosyltransferases
    2.4.2.30  NAD+ ADP-ribosyltransferase
     25591 (Parp1)
DNA replication proteins [BR:rno03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    25591 (Parp1)
Chromosome and associated proteins [BR:rno03036]
 Eukaryotic type
  Centrosome formation proteins
   Centriole proteins
    25591 (Parp1)
DNA repair and recombination proteins [BR:rno03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    Other BER factors
     25591 (Parp1)
SSDB
Motif
Pfam: PARP PARP_reg zf-PARP PADR1_N WGR PADR1_Zn_ribbon BRCT BRCT_2
Other DBs
NCBI-GeneID: 25591
NCBI-ProteinID: NP_037195
RGD: 2053
Ensembl: ENSRNOG00000003084
UniProt: P27008 A6JGH1
Structure
Position
13:94839484..94871295
AA seq 1014 aa
MAEATERLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GHSIRQPDTEVDGFSELRWDDQQKVKKTAEAGGVAGKGQHGGGGKAEKTLGDFAAEYAKS
NRSTCKGCMEKIEKGQMRLSKKMLDPEKPQLGMIDRWYHPTCFVKNRDELGFRPEYSASQ
LKGFSLLSAEDKEALKKQLPAVKSEGKRKCDEVDGIDEVAKKKSKKGKDKESSKLEKALK
AQNELVWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECS
GQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKIKKQDRLFPP
ESSAPAPPAPPVSITSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAMIEKLGGKL
TGSANKASLCISTKKEVEKMSKKMEEVKAANVRVVCEDFLQDVSASAKSLQELLSAHSLS
SWGAEVKVEPGEVVVPKGKSAAPSKKSKGAVKEEGVNKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLESDKESRYWIFRSWGRVGTVIGSNK
LEQMPSKEDAVEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLAVKPG
TKSKLPKPVQELVGMIFDVESMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQAV
SQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNTDSVQAKVEMLDNLLDIEVAYSLLRG
GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIE
REGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTAPDPSA
SITLDGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
NT seq 3045 nt   +upstreamnt  +downstreamnt
atggcggaggccacggagaggctttaccgagtggagtacgctaagagcgggcgcgcctct
tgcaagaaatgcagcgagagtatccccaaggactcgctccgcatggccatcatggtgcag
tcacccatgttcgatggaaaagtcccacactggtatcacttctcctgcttctggaaggtg
ggccactccatccggcagcctgacacagaggtggacgggttctctgagctgcggtgggat
gaccagcagaaggtcaagaagaccgcagaggctggaggcgtggcaggcaaaggccagcat
ggaggtggcggcaaggcggagaagacgctgggcgactttgcggcagagtatgccaagtcc
aacaggagcacatgcaagggctgcatggagaagatagagaagggtcagatgcgcctgtcc
aagaagatgctggatccagagaagccgcaactgggtatgattgaccgctggtaccatcca
acttgctttgtcaagaaccgggacgagctgggcttccggcctgagtacagtgccagccag
ctcaagggctttagcctcctctctgcagaagacaaagaagctctgaagaagcagctcccg
gcagtcaagagtgaaggaaagagaaaatgtgacgaggtggatggaatagatgaagtagcc
aaaaagaaatctaaaaaaggaaaggacaaggagagtagtaaactggaaaaggcgctcaag
gctcagaacgagctggtctggaatatcaaagatgagctgaagaaagcctgctccaccaac
gacctgaaggagttgctcatcttcaaccagcagcaagtaccatctggagagtccgcaatc
ctggaccgagttgctgatggcatggcgtttggggcccttctgccctgcaaggagtgttca
ggacagctggtttttaagagcgacgcttattactgtactggggatgtcactgcctggacc
aagtgcatggtcaagacacagaatcccagccgaaaggaatgggtaactccaaaggaattc
cgagaaatatcctacctcaagaaattaaagatcaaaaagcaggaccggctgttccctcca
gagagcagcgccccagcaccaccagcacctcccgtctcgatcacctccgcacccacagct
gtgaactcctctgcaccagcagacaaacccctgtctaacatgaagatcctgactcttggt
aagctctcccagaacaaggacgaagcaaaggccatgattgagaaactcggaggcaagctg
acaggatctgccaacaaggcctccttgtgtatcagcactaagaaggaggtggagaagatg
agtaagaagatggaggaagtgaaagcagccaatgttcgagtcgtgtgtgaggacttcctc
caggatgtgtctgcctcagctaagagcctccaagagctgctctcagcccatagcttgtcc
tcgtggggggctgaggtgaaggtagagcctggtgaagtggtggtccccaaggggaagtca
gctgcaccctccaagaagagcaagggtgctgtcaaggaggaaggtgtcaacaagtctgaa
aagaggatgaaactaactctgaagggaggagcagccgttgatcctgactctggtctggaa
cactctgcacatgtcctggagaaaggcgggaaggtgttcagtgccacgcttggcctggtg
gacattgtgaaagggactaactcctattacaaactgcaacttctggagtccgacaaggag
agcaggtattggatcttccggtcctggggccgagtgggcacagttatcggcagtaacaag
cttgagcagatgccgtccaaagaggatgctgttgaacacttcatgaagttatacgaagag
aagactggaaatgcctggcactcgaaaaacttcacaaagtatcccaagaagttctaccct
ctggagattgactatggccaggacgaagaggcagtaaagaagctggcggtgaagcctggc
actaagtcgaagctgccgaagccggtgcaggagctcgtcgggatgatcttcgacgtggag
agcatgaagaaggccttggtggagtacgagattgaccttcagaagatgcccttggggaaa
ctgagcagaaggcagatccaggccgcctactctatcctcagtgaggtccagcaggcagtg
tcccaaggcagcagtgaatctcagatcctggatctctccaatcgcttctacaccctcatc
ccccatgactttggaatgaagaagcccccacttctgaacaacacagacagtgtgcaggcc
aaggtggagatgctggacaacctcctggacatcgaggttgcctatagtcttctcaggggt
gggtctgatgacagcagtaaggaccccatcgatgtcaactatgagaagctcaaaactgac
attaaggtggttgacagagattctgaagaggctgaggtcatcaggaagtatgtgaagaac
actcacgcgaccacgcacaatgcctatgacctggaagtgatagacatctttaagatagag
cgagagggagagagccaacgctacaagcccttcaggcagcttcacaaccggagactgctg
tggcacgggtccaggaccaccaacttcgcaggcatcctgtcacagggtctgcggatagcc
ccacctgaagcacctgtgacaggctacatgtttgggaaaggaatctactttgctgatatg
gtgtccaaaagtgcgaactactgccacacgtctcagggagacccgattggcttaatactg
ttgggagaagttgcccttggaaacatgtacgaactcaagcatgcttctcacatcagcaag
ttacccaagggcaagcacagtgtcaaaggtttgggcaaaaccgcccctgacccttcggcc
agcatcaccctggatggtgtagaggttccgctgggaacagggattccgtctggtgttaat
gacacctgcctgctgtataacgagtacattgtctacgacattgctcaggtgaatctgaag
tacctactgaaactgaagttcaatttcaagacctccttgtggtag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (5)   
   KEGG PATHWAY (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   RGD (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (40)   

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